The area was originally part of the Pejepscot Purchase, land bought in 1714 by an association of people from Boston and Portsmouth following the Treaty of Portsmouth, which brought peace between the Abenaki Indians and the settlers of present-day Maine. In 1736, however, the Massachusetts General Court granted a large section of the land to veterans of the 1690 Battle of Quebec. Conflicting claims led to prolonged litigation; consequently, settlement was delayed until after the French and Indian Wars.

Auburn was first settled in 1786 as part of Bakerstown, renamed Poland when it was incorporated by the Massachusetts General Court in 1795. It was then part of Minot, formed from parts of Poland and incorporated in 1802. Auburn would itself be formed from parts of Minot and incorporated on February 24, 1842. The name was apparently inspired by “Auburn”, a village (real or fictitious) featured in the 1770 poem “The Deserted Village” by Oliver Goldsmith. Originally part of Cumberland County, the town became county seat of Androscoggin County at its creation in 1854. By annexing land from towns around it, including part of Poland in 1852, Minot in 1873, and all of Danville (first called Pejepscot) in 1867, Auburn grew geographically into one of Maine’s largest municipalities. Incorporated as a city on February 22, 1869, Auburn in 1917 would be the first city in the state to adopt a council-manager form of government.

Farms supplied grain and produce, but with construction of the bridge across the river to Lewiston in 1823, and especially after arrival of the Atlantic and St. Lawrence Railroad from Portland in January 1848, the community developed into a mill town. Mills were built to operate by water power from falls on the Androscoggin River and Little Androscoggin River. In 1835, the factory system of shoe manufacture originated at Auburn. Other firms manufactured cotton and woolen textiles, carriages, iron goods, bricks and furniture. The population in 1860 was only about 4,000 but by 1890 it had tripled to 12,000 as a result of its shoe factories attracting many French Canadian immigrants, many of whom arrived by train from Quebec. Steady population growth continued until around 1960, plateauing at roughly 24,500.